The goal of the Dependency Map (DepMap) portal is to empower the research community to make discoveries related to cancer vulnerabilities by providing open access to key cancer dependencies analytical and visualization tools. It would systematically map cancer vulnerabilities by perturbing genes and proteins across many cancer types as well as across clinical stages and settings. The Cancer Dependency Map would collect different data and ask different questions from sequencing projects by looking at the experimental effects of perturbations (see Boehm et al., Nature 589:514, 2021). Registration not required.