Lucy was designed and written at The Institute for Genomic Research (TIGR, now the J. Craig Venter Institute), and it has been used here for several years to clean sequence data from automated DNA sequencers prior to sequence assembly and other downstream uses. The quality trimming portion of lucy makes use of phred quality scores, such as those produced by many automated sequencers based on the Sanger sequencing method. As such, lucy’s quality trimming may not be appropriate for sequence data produced by some of the new “next-generation” sequencers. Lucy is available in the form of a software download only. I currently have no plans to create an open-source community development project for lucy. If you think that would be valuable, please contact me about it. In the meantime, the download package includes the full source code, so feel free to customize it for your environment. Registration not required.