The Probe Miner: Objective Assessment of Chemical Probes is a community resource for the evaluation of chemical probes based on large-scale, publicly available, medicinal chemistry data. It is intended to empower researchers to select the best probes based on objective, data driven criteria. This resource provides evaluation of > 1.8m small molecules against for >2,200 human targets and is regularly updated in response to updates in the publicly available medicinal chemistry data. Our continuing data curation efforts will ensure that this resource is continually evolving and improving. Registration not required.