Sequerome is a web-based Sequence profiling tool that provides a unique and useful functionality of seamlessly integrating the results of an entire BLAST sequence-alignment report to a panel of external research tools/servers that perform advanced sequence manipulations, and allowing the user to record the steps of such an analysis. Free access to information is not so much an issue as free ability to analyze and organize data in simple user-friendly interfaces. This is especially true for experimental molecular biologists who perform a series of sequence manipulations by visiting multiple sources before using the processed data further in their experiments. Biologists often perform sequence homology studies using the Basic Local Alignment Search Tool BLAST. The output of the results interface provides very limited access to sequence analysis tools, such as restriction enzyme maps for DNA sequences and secondary structure prediction for protein sequences. This is further compounded by the inability to navigate smoothly between different sequence alignment records. Such needs would be better met by a single interface that would allow a user to directly link each of the sequences from alignment reports to different domains/servers offering analysis and manipulation options. Sequerome, a web based Java tool, was developed to meet this end by acting as a front-end to BLAST queries and providing simplified access to web-distributed resources for protein and nucleic acid analysis. Despite the limited scope offered at present, the application is likely to mushroom the growth of related software tools that expand the scope and coverage of molecular biology tools. Registration not required.